What drugs should not be taken with benzonatate?

Drug Interactions with Benzonatate: What to Avoid

Published on September 16, 2023

Benzonatate is a commonly prescribed medication for relieving cough symptoms associated with the common cold or respiratory infections. While it can be highly effective, it's essential to be aware of potential drug interactions that can impact your safety and the medication's efficacy. Here's a guide to drugs that should not be taken with benzonatate or should be used with caution:

1. Alcohol

Combining benzonatate with alcohol can intensify side effects like drowsiness and dizziness. It's advisable to avoid alcohol while taking this medication to prevent unwanted interactions.

2. Central Nervous System (CNS) Depressants

Benzonatate has sedative effects. When taken with other CNS depressants, such as sedative-hypnotics, tranquilizers, or certain antipsychotic drugs, it can lead to excessive sedation and respiratory depression. This combination can be dangerous and should be avoided.

How to Stay Safe with Benzonatate

It's crucial to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking. They can provide guidance on the safe use of benzonatate and potential interactions with other drugs. Always follow your healthcare provider's instructions and the medication label's directions when taking benzonatate or any other medication. If you experience any unusual side effects or reactions, contact your healthcare provider immediately.

3. Opioid Medications

Opioid drugs, such as codeine or hydrocodone, can also depress the central nervous system. When combined with benzonatate, it may result in excessive sedation and respiratory depression. This combination should only be used under medical supervision and with caution.

4. Muscle Relaxants

Medications acting as muscle relaxants, like cyclobenzaprine, can enhance sedative effects when taken alongside benzonatate. Caution is advised when combining these drugs, and it's best to consult your healthcare provider.

5. Antihistamines

Some antihistamines, particularly first-generation ones like diphenhydramine (Benadryl), can cause drowsiness. When taken with benzonatate, it may intensify sedative effects. Be mindful of this interaction and consider alternatives if needed.

6. Certain Antidepressants

Tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) can interact with benzonatate, potentially leading to increased sedation and other side effects. Discuss your medication history with your healthcare provider to ensure safe use.

7. Anti-Anxiety Medications

Benzodiazepines and other anti-anxiety medications can interact with benzonatate, potentially causing increased drowsiness and impaired coordination. Your healthcare provider can provide guidance on managing this interaction.

8. Gastroesophageal Reflux Disease (GERD) Medications

Some medications used to treat GERD, like proton pump inhibitors (PPIs), may affect the absorption of benzonatate. To ensure its effectiveness, take benzonatate on an empty stomach or as directed by your healthcare provider.

9. Anticholinergic Drugs

Medications with anticholinergic effects, including certain antipsychotic medications, can interact with benzonatate, potentially leading to side effects like dry mouth and constipation. Be cautious when using these medications concurrently.

10. Herbal Supplements

Some herbal supplements and remedies may interact with benzonatate. It's crucial to consult with your healthcare provider or a qualified herbalist before combining herbal products with this medication. Natural does not always mean safe when it comes to drug interactions.

11. Over-the-Counter (OTC) Cough Medications

Using over-the-counter cough medications alongside benzonatate may lead to excessive suppression of cough reflexes. This can hinder the body's ability to clear mucus and irritants from the airways. Consult your healthcare provider for guidance on managing cough symptoms.

12. Blood Pressure Medications

Individuals taking blood pressure medications, particularly those that lower blood pressure, should exercise caution when using benzonatate. The combined effect may result in low blood pressure, leading to dizziness or fainting. Regular monitoring by a healthcare professional is essential.

13. Anticoagulants (Blood Thinners)

If you are on anticoagulant medications like warfarin or heparin, be cautious when taking benzonatate. Some interactions may affect blood clotting mechanisms. Regular monitoring of your blood's clotting time is necessary when combining these drugs.

14. Allergies and Sensitivities

If you have known allergies or sensitivities to medications, consult your healthcare provider before using benzonatate. While it is primarily used to relieve cough symptoms, it's essential to ensure that it does not contain any components to which you are allergic.

15. Pre-existing Medical Conditions

Individuals with certain medical conditions, such as asthma or chronic obstructive pulmonary disease (COPD), should use benzonatate with caution. It may not be suitable for everyone, and your healthcare provider can determine the best course of treatment for your specific condition.

Final Thoughts

Understanding potential drug interactions is crucial for safe and effective medication use. Always follow your healthcare provider's recommendations and inform them of any changes in your medication regimen. Your well-being is their priority, and they can help you make informed decisions about your health.

THis is general Advisory contant with your doctor for individual conditions